Books

PUBLICATIONS

2021

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Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent “Ene”-Reductases

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Activation modes in biocatalytic radical cyclization reactions

Yuxuan Ye,  Haigen Fu,  Todd K Hyster*

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Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins

Claire G. Page, Simon J. Cooper, Jacob S. DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Alyssa H. Antropow, Kurt W. Armbrust, J. Michael Ellis, Lawrence G. Hamann, Evan J. Horn, Kevin M. Oberg, Gregory D. Scholes, and Todd K. Hyster*

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Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C–C Bond Forming Reactions

Haigen Fu, Heather Lam, Megan A. Emmanuel, Ji Hye Kim, Braddock A. Sandoval, and Todd K. Hyster*

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Photoenzymatic Reductions Enabled by Direct Excitation of Flavin-Dependent “Ene”-Reductases

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Light-Driven Flavin-Based Biocatalysis

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2020

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Active-Site Environmental Factors Customize the Photophysics of Photoenzymatic Old Yellow Enzymes

Bryan Kudisch, Daniel G. Oblinsky, Michael J. Black, Anna Zieleniewska, Megan A. Emmanuel, Garry Rumbles, Todd K. Hyster, and Gregory D. Scholes*

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Photoenzymatic Generation of Unstabilized Alkyl Radicals: An Asymmetric Reductive Cyclization

Phillip D. Clayman and Todd K. Hyster*

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Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones

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Pyridoxal-Catalyzed Racemization of α-Aminoketones Enables the Stereodivergent Synthesis of 1,2-Amino Alcohols Using Ketoreductases

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Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts

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Emerging strategies for expanding the toolbox of enzymes in biocatalysis

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2019

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Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases

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Radical Biocatalysis: Using Non-Natural Single Electron Transfer  Mechanisms to Access New Enzymatic Functions

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Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases

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Biocatalytic hydrogen atom transfer: an invigorating approach to free-radical reactions

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2018

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Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases

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2017

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Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent ‘Ene’-Reductases

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2016

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Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light

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