Books

PUBLICATIONS

2022

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Haigen Fu, Jingzhe Cao, Tianzhang Qiao, Yuyin Qi, Simon J. Charnock, Samuel Garfinkle, Todd K. Hyster*

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Photoinduced Dynamic Radical Processes for Isomerizations, Deracemizations, and Dynamic Kinetic Resolutions

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Radical Termination via β-Scission Enables Photoenzymatic Allylic Alkylation Using “Ene”-Reductases

Netgie Laguerre, Paul S. Riehl, Daniel G. Oblinsky, Megan A. Emmanuel, Michael J. Black, Gregory D. Scholes, and Todd K. Hyster*

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Using Enzymes to Tame Nitrogen-Centered Radicals for Enantioselective Hydroamination

Yuxuan Ye†, Jingzhe Cao†, Daniel G. Oblinsky, Deeptak Verma, Christopher K. Prier, Gregory D. Scholes & Todd K. Hyster*

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Cell-Free CO2 Valorization to C6 Pharmaceutical Precursors via a Novel Electro-Enzymatic Process

Joshua Jack, Haigen Fu, Aaron Leininger, Todd K. Hyster, and Zhiyong  Jason Ren

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A Photoenzyme for Challenging Lactam Radical Cyclizations

Bryce T. Nicholls, Tianzhang Qiao, Todd K. Hyster

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An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Catalysis

Paul S. Riehl, Jesmine Lim, James D. Finnigan, Simon J. Charnock, Todd K. Hyster

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Workflow for Biocatalytic Reaction Performance Prediction and Analysis

Hanna D. Clements†, Autumn R. Flynn†, Bryce T. Nicholls, Daria Grosheva, Todd K. Hyster*, and Matthew S. Sigman*

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2021

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Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent “Ene”-Reductases

Xin Gao, Joshua R. Turek-Herman, Young Joo Choi, Ryan D. Cohen, and Todd K. Hyster*

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Engineering a Non-Natural Photoenzyme for Improved Photon Efficiency

Bryce Nicholls, Daniel Oblinsky, Sarah Kurtoic, Daria Grosheva, Yuxuan Ye, Gregory Scholes, Todd Hyster*

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Activation modes in biocatalytic radical cyclization reactions

Yuxuan Ye,  Haigen Fu,  Todd K Hyster*

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Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins

Claire G. Page, Simon J. Cooper, Jacob S. DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Alyssa H. Antropow, Kurt W. Armbrust, J. Michael Ellis, Lawrence G. Hamann, Evan J. Horn, Kevin M. Oberg, Gregory D. Scholes, and Todd K. Hyster*

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Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C–C Bond Forming Reactions

Haigen Fu, Heather Lam, Megan A. Emmanuel, Ji Hye Kim, Braddock A. Sandoval, and Todd K. Hyster*

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Photoenzymatic Reductions Enabled by Direct Excitation of Flavin-Dependent “Ene”-Reductases

Braddock A. Sandoval, Phillip D. Clayman, Daniel G. Oblinsky, Seokjoon Oh, Yuji Nakano, Matthew Bird, Gregory D. Scholes, and Todd K. Hyster*

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Light-Driven Flavin-Based Biocatalysis

Daria Grosheva, Todd K. Hyster*

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2020

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Active-Site Environmental Factors Customize the Photophysics of Photoenzymatic Old Yellow Enzymes

Bryan Kudisch, Daniel G. Oblinsky, Michael J. Black, Anna Zieleniewska, Megan A. Emmanuel, Garry Rumbles, Todd K. Hyster, and Gregory D. Scholes*

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Photoenzymatic Generation of Unstabilized Alkyl Radicals: An Asymmetric Reductive Cyclization

Phillip D. Clayman and Todd K. Hyster*

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Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones

Jacob S. DeHovitz,Yong Yao Loh, Jacob A. Kautzky, Kazunori Nagao, Andrew J. Meichan, Motoshi Yamauchi, David W. C. MacMillan*, Todd K. Hyster*

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Pyridoxal-Catalyzed Racemization of α-Aminoketones Enables the Stereodivergent Synthesis of 1,2-Amino Alcohols Using Ketoreductases

 Jingzhe Cao and Todd K. Hyster*

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Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts

Yuji Nakano, Michael J Black, Andrew J. Meichan, Braddock A Sandoval, Megan Chung, Kyle Biegasiewicz, Tianyu Zhu, Todd K. Hyster*

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Emerging strategies for expanding the toolbox of enzymes in biocatalysis

Braddock A. Sandoval, Todd K. Hyster*

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2019

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Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases

Michael J. Black, Kyle F. Biegasiewicz, Andrew J. Meichan, Daniel G. Oblinsky, Bryan Kudisch, Gregory Scholes, Todd Hyster*

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Radical Biocatalysis: Using Non-Natural Single Electron Transfer  Mechanisms to Access New Enzymatic Functions

Todd K. Hyster

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Photoexcitation of flavoenzymes enables a stereoselective radical cyclization

Kyle F. Biegasiewicz, Simon J. Cooper, Xin Gao, Daniel G. Oblinsky, Ji Hye Kim, Samuel E. Garfinkle, Leo A. Joyce, Braddock A. Sandoval, Gregory D. Scholes*, Todd K. Hyster*

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Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases

Braddock A. Sandoval, Sarah I. Kurtoic, Megan M. Chung, Kyle F. Biegasiewicz, Todd K. Hyster*

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Biocatalytic hydrogen atom transfer: an invigorating approach to free-radical reactions

Yuji Nakano, Kyle F Biegasiewicz, Todd K Hyster*

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2018

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Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases

Kyle F. Biegasiewicz, Simon J. Cooper, Megan A. Emmanuel, David C. Miller* & Todd K. Hyster*

2017

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Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent ‘Ene’-Reductases

Braddock A. Sandoval, Andrew J. Meichan, Todd K. Hyster*

2016

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Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light

Megan A. Emmanuel, Norman R. Greenberg, Daniel G. Oblinsky, Todd K. Hyster*

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