
PUBLICATIONS
2022

An Asymmetric sp3–sp3 Cross-Electrophile Coupling Using Biocatalysis

A Photoenzyme for Challenging Lactam Radical Cyclizations

Using Enzymes to Tame Nitrogen-Centered Radicals for Enantioselective Hydroamination



An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Catalysis


Workflow for Biocatalytic Reaction Performance Prediction and Analysis

2021

Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent “Ene”-Reductases


Engineering a Non-Natural Photoenzyme for Improved Photon Efficiency


Activation modes in biocatalytic radical cyclization reactions
Yuxuan Ye, Haigen Fu, Todd K Hyster*


Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins
Claire G. Page, Simon J. Cooper, Jacob S. DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Alyssa H. Antropow, Kurt W. Armbrust, J. Michael Ellis, Lawrence G. Hamann, Evan J. Horn, Kevin M. Oberg, Gregory D. Scholes, and Todd K. Hyster*


Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C–C Bond Forming Reactions
Haigen Fu, Heather Lam, Megan A. Emmanuel, Ji Hye Kim, Braddock A. Sandoval, and Todd K. Hyster*


Photoenzymatic Reductions Enabled by Direct Excitation of Flavin-Dependent “Ene”-Reductases


2020

Active-Site Environmental Factors Customize the Photophysics of Photoenzymatic Old Yellow Enzymes
Bryan Kudisch, Daniel G. Oblinsky, Michael J. Black, Anna Zieleniewska, Megan A. Emmanuel, Garry Rumbles, Todd K. Hyster, and Gregory D. Scholes*

Photoenzymatic Generation of Unstabilized Alkyl Radicals: An Asymmetric Reductive Cyclization
Phillip D. Clayman and Todd K. Hyster*



Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones


Pyridoxal-Catalyzed Racemization of α-Aminoketones Enables the Stereodivergent Synthesis of 1,2-Amino Alcohols Using Ketoreductases


Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts


Emerging strategies for expanding the toolbox of enzymes in biocatalysis



2019

Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases


Radical Biocatalysis: Using Non-Natural Single Electron Transfer Mechanisms to Access New Enzymatic Functions


Photoexcitation of flavoenzymes enables a stereoselective radical cyclization


Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases


Biocatalytic hydrogen atom transfer: an invigorating approach to free-radical reactions

2018

Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases

2017

Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent ‘Ene’-Reductases

2016

Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light
