PUBLICATIONS

2024

Asymmetric Synthesis of 𝛼-Chloroamides via Photoenzymatic Hydroalkylation of Olefins

J. Am. Chem. Soc. 2024, 146, 11, 7191–7197

Yi Liu, Sophie G. Bender, Damien Sorigue, Daniel J. Diaz, Andrew D. Ellington, Greg Mann, Simon Allmendinger, and Todd K. Hyster

Regiodivergent Radical Termination for Intermolecular Biocatalytic C–C Bond Formation

J. Am. Chem. Soc. 2024, 146, 7, 5005-5010

Mark R. Petchey, Yuxuan Ye, Victor Spelling, James D. Finnigan, Samantha Gittings, Magnus J. Johansson, Martin A. Hayes, and Todd K. Hyster

Enantioselective decarboxylative alkylation using synergistic photoenzymatic catalysis

Nat. Catal. 2024, 7, 35-42

Shang-Zheng Sun, Bryce T. Nicholls, David Bain, Tianzhang Qiao, Claire G. Page, Andrew J. Musser, and Todd K. Hyster

2023

Evidence of a Distinctive Enantioselective Binding Mode for the Photoinduced Radical Cyclization of 𝛼-Chloroamides in Ene-Reductases

ACS Catal. 2023, 13, 15310-15321

Matteo Capone, Gianluca Dell'Orletta, Bryce T. Nicholls, Gregory D. Scholes, Todd K. Hyster, Massimiliano Aschi, Isabella Daidone

Pyridylmethyl Radicals for Enantioselective Alkene Hydroalkylation Using “Ene”-Reductases

ACS Catal. 2023, 13, 14680–14684

Sophie G. Bender and Todd K. Hyster

Using Data Science for Mechanistic Insights and Selectivity Predictions in a Non-Natural Biocatalytic Reaction

J. Am. Chem. Soc. 2023, 145, 32, 17656-17664

Hanna D. Clements, Autumn R. Flynn, Bryce T. Nicholls, Daria Grosheva, Sarah J. Lefave, Morgan T. Merriman, Todd K. Hyster, Matthew S. Sigman

Synthesis of 𝛽-Quaternary Lactams Using Photoenzymatic Catalysis

Asian J. Org. Chem. 2023, 12 (8), e202300274

Joshua R. Turek-Herman, Mike Rosenberger, Todd K. Hyster

Asymmetric Carbohydroxylation of Alkenes Using Photoenzymatic Catalysis

J. Am. Chem. Soc. 2023, 145, 31, 17018-17022

Yao Ouyang, Joshua Turek-Herman, Tianzhang Qiao, Todd K. Hyster

Mechanism and Dynamics of Photodecarboxylation Catalyzed by Lactate Monooxygenase

J. Am. Chem. Soc. 2023, 145, 24, 13232-13240

Xiankun Li, Claire G. Page, Laura Zanetti-Polzi, Aarat P. Kalra, Daniel G. Oblinsky, Isabella Daidone, Todd K. Hyster, and Gregory D. Scholes

Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes

J. Am. Chem. Soc. 2023, 145, 21, 11866-11874

Claire G. Page, Jingzhe Cao, Daniel G. Oblinsky, Samantha N. MacMillan, Shiva Dahagam, Ruth M. Lloyd, Simon J. Charnock, Gregory D. Scholes, and Todd K. Hyster

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Photobiocatalytic Strategies for Organic Synthesis

Chem. Rev. 2023, 123, 9, 5459-5520

Megan A. Emmanuel, Sophie G. Bender, Catherine Bilodeau, Jose M. Carceller, Jacob S. DeHovitz, Haigen Fu, Yi Liu, Bryce T. Nicholls, Yao Ouyang, Claire G. Page, Tianzhang Qiao, Felix C. Raps, Damien R. Sorigué, Shang-Zheng Sun, Joshua Turek-Herman, Yuxuan Ye, Ariadna Rivas-Souchet, Jingzhe Cao, and Todd K. Hyster

Asymmetric C-Alkylation of Nitroalkanes via Enzymatic Photoredox Catalysis

J. Am. Chem. Soc. 2023, 145, 2, 787-793

Haigen Fu, Tianzhang Qiao, Jose M. Carceller, Samantha N. MacMillan, and Todd K. Hyster

2022

Using enzymes to tame nitrogen-centred radicals for enantioselective hydroamination

Nat. Chem. 2023, 15, 206-212

Yuxuan Ye, Jingzhe Cao, Daniel G. Oblinsky, Deeptak Verma, Christopher K. Prier, Gregory D. Scholes, and Todd K. Hyster

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Photoenzymatic Catalysis in a New Light: Gluconobacter “Ene”-Reductase Conjugates Possessing High-Energy Reactivity with Tunable Low-Energy Excitation

J. Am. Chem. Soc. 2022, 144, 38, 17516-17521

Paul T. Cesana, Claire G. Page, Dvir Harris, Megan A. Emmanuel, Todd K. Hyster, and Gabriela S. Schlau-Cohen*

An asymmetric sp3–sp3 cross-electrophile coupling using ‘ene’-reductases

Nature 2022, 610, 302-307

Haigen Fu, Jingzhe Cao, Tianzhang Qiao, Yuyin Qi, Simon J. Charnock, Samuel Garfinkle, and Todd K. Hyster

Radical Termination via β-Scission Enables Photoenzymatic Allylic Alkylation Using “Ene”-Reductases

ACS Catal. 2022, 12, 15, 9801-9805

Netgie Laguerre, Paul S. Riehl, Daniel G. Oblinsky, Megan A. Emmanuel, Michael J. Black, Gregory D. Scholes, and Todd K. Hyster

Photoinduced Dynamic Radical Processes for Isomerizations, Deracemizations, and Dynamic Kinetic Resolutions

ACS Catal. 2022, 12, 15, 8911-8924

Jacob S. DeHovitz and Todd K. Hyster

Cell-Free CO2 Valorization to C6 Pharmaceutical Precursors via a Novel Electro-Enzymatic Process

ACS Sustainable Chem. Eng. 2022, 10, 13, 4114-4121

Joshua Jack, Haigen Fu, Aaron Leininger, Todd K. Hyster, and Zhiyong Jason Ren

A Photoenzyme for Challenging Lactam Radical Cyclizations

Synlett 2022, 33, 12, 1204-1208

Bryce T. Nicholls, Tianzhang Qiao, and Todd K. Hyster

An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Catalysis

Org. Process Res. Dev. 2022, 26, 7, 2096-2101

Paul S. Riehl, Jesmine Lim, James D. Finnigan, Simon J. Charnock, and Todd K. Hyster

2021

Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent “Ene”-Reductases

J. Am. Chem. Soc. 2021, 143, 47, 19643-19647

Xin Gao, Joshua R. Turek-Herman, Young Joo Choi, Ryan D. Cohen, and Todd K. Hyster

Engineering a Non-Natural Photoenzyme for Improved Photon Efficiency

Angew. Chem. Int. Ed. 2022, 61, e202113842

Bryce T. Nicholls, Daniel G. Oblinsky, Sarah I. Kurtoic, Daria Grosheva, Yuxuan Ye, Gregory D. Scholes, and Todd K. Hyster

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Activation modes in biocatalytic radical cyclization reactions

J. Ind. Microbiol. Biotechnol. 2021, 48, kuab021

Yuxuan Ye, Haigen Fu, and Todd K. Hyster

Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C–C Bond Forming Reactions

J. Am. Chem. Soc. 2021, 143, 25, 9622-9629

Haigen Fu, Heather Lam, Megan A. Emmanuel, Ji Hye Kim, Braddock A. Sandoval, and Todd K. Hyster

Light-Driven Flavin-Based Biocatalysis

Flavin-Based Catalysis: Principles and Applications, Chapter 12, 2021

Daria Grosheva and Todd K. Hyster

Photoenzymatic Reductions Enabled by Direct Excitation of Flavin-Dependent “Ene”-Reductases

J. Am. Chem. Soc. 2021, 143, 4, 1735-1739

Braddock A. Sandoval, Phillip D. Clayman, Daniel G. Oblinsky, Seokjoon Oh, Yuji Nakano, Matthew Bird, Gregory D. Scholes, and Todd K. Hyster

Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins

J. Am. Chem. Soc. 2021, 143, 1, 97-102.

Claire G. Page, Simon J. Cooper, Jacob S. DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Alyssa H. Antropow, Kurt W. Armbrust, J. Michael Ellis, Lawrence G. Hamann, Evan J. Horn, Kevin M. Oberg, Gregory D. Scholes, and Todd K. Hyster

2020

Active-Site Environmental Factors Customize the Photophysics of Photoenzymatic Old Yellow Enzymes

J. Phys. Chem. B 2020, 124, 49, 11236-11249

Bryan Kudisch, Daniel G. Oblinsky, Michael J. Black, Anna Zieleniewska, Megan A. Emmanuel, Garry Rumbles, Todd K. Hyster, and Gregory D. Scholes

Photoenzymatic Generation of Unstabilized Alkyl Radicals: An Asymmetric Reductive Cyclization

J. Am. Chem. Soc. 2020, 142, 37, 15673-15677

Phillip D. Clayman and Todd K. Hyster

Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones

Science 2020, 369, 1113-1118

Jacob S. DeHovitz,Yong Yao Loh, Jacob A. Kautzky, Kazunori Nagao, Andrew J. Meichan, Motoshi Yamauchi, David W. C. MacMillan, and Todd K. Hyster

Pyridoxal-Catalyzed Racemization of α-Aminoketones Enables the Stereodivergent Synthesis of 1,2-Amino Alcohols Using Ketoreductases

ACS Catal. 2020, 10, 6171-6175

Jingzhe Cao and Todd K. Hyster

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Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts

Angew. Chem. Int. Ed. 2020, 59, 10484-10488

Yuji Nakano, Michael J. Black, Andrew J. Meichan, Braddock A. Sandoval, Megan Chung, Kyle Biegasiewicz, Tianyu Zhu, and Todd K. Hyster

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Emerging strategies for expanding the toolbox of enzymes in biocatalysis

Curr. Opin. Chem. Biol. 2020, 55, 45-51

Braddock A. Sandoval and Todd K. Hyster

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2019

Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases

Nat. Chem. 2019, 12, 71-75

Michael J. Black, Kyle F. Biegasiewicz, Andrew J. Meichan, Daniel G. Oblinsky, Bryan Kudisch, Gregory Scholes, and Todd Hyster

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Radical Biocatalysis: Using Non-Natural Single Electron Transfer Mechanisms to Access New Enzymatic Functions

Synlett 2020, 31, 3, 248-254

Todd K. Hyster

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Photoexcitation of flavoenzymes enables a stereoselective radical cyclization

Science 2019, 364, 1166-1169

Kyle F. Biegasiewicz, Simon J. Cooper, Xin Gao, Daniel G. Oblinsky, Ji Hye Kim, Samuel E. Garfinkle, Leo A. Joyce, Braddock A. Sandoval, Gregory D. Scholes, and Todd K. Hyster