Activation modes in biocatalytic radical cyclization reactions

Yuxuan Ye,  Haigen Fu,  Todd K Hyster*

Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C–C Bond Forming Reactions

Haigen Fu, Heather Lam, Megan A. Emmanuel, Ji Hye Kim, Braddock A. Sandoval, and Todd K. Hyster*

Chapter 12

Light-Driven Flavin-Based Biocatalysis

Daria Grosheva, Todd K. Hyster*

Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins

Claire G. Page, Simon J. Cooper, Jacob S. DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Alyssa H. Antropow, Kurt W. Armbrust, J. Michael Ellis, Lawrence G. Hamann, Evan J. Horn, Kevin M. Oberg, Gregory D. Scholes, and Todd K. Hyster*

Active-Site Environmental Factors Customize the Photophysics of Photoenzymatic Old Yellow Enzymes

Bryan Kudisch, Daniel G. Oblinsky, Michael J. Black, Anna Zieleniewska, Megan A. Emmanuel, Garry Rumbles, Todd K. Hyster, and Gregory D. Scholes*

Photoenzymatic Generation of Unstabilized Alkyl Radicals: An Asymmetric Reductive Cyclization

Phillip D. Clayman and Todd K. Hyster*

Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones

Jacob S. DeHovitz,Yong Yao Loh, Jacob A. Kautzky, Kazunori Nagao, Andrew J. Meichan, Motoshi Yamauchi, David W. C. MacMillan*, Todd K. Hyster*

Pyridoxal-Catalyzed Racemization of α-Aminoketones Enables the Stereodivergent Synthesis of 1,2-Amino Alcohols Using Ketoreductases

 Jingzhe Cao and Todd K. Hyster*

Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts

Yuji Nakano, Michael J Black, Andrew J. Meichan, Braddock A Sandoval, Megan Chung, Kyle Biegasiewicz, Tianyu Zhu, Todd K. Hyster*

Emerging strategies for expanding the toolbox of enzymes in biocatalysis

Braddock A. Sandoval, Todd K. Hyster*

Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases

Michael J. Black, Kyle F. Biegasiewicz, Andrew J. Meichan, Daniel G. Oblinsky, Bryan Kudisch, Gregory Scholes, Todd Hyster*

Photoexcitation of flavoenzymes enables a stereoselective radical cyclization

Kyle F. Biegasiewicz, Simon J. Cooper, Xin Gao, Daniel G. Oblinsky, Ji Hye Kim, Samuel E. Garfinkle, Leo A. Joyce, Braddock A. Sandoval, Gregory D. Scholes*, Todd K. Hyster*

Radical Biocatalysis: Using Non-Natural Single Electron Transfer  Mechanisms to Access New Enzymatic Functions

Todd K. Hyster

Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases

Braddock A. Sandoval, Sarah I. Kurtoic, Megan M. Chung, Kyle F. Biegasiewicz, Todd K. Hyster*

Biocatalytic hydrogen atom transfer: an invigorating approach to free-radical reactions

Yuji Nakano, Kyle F Biegasiewicz, Todd K Hyster*

Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases

Kyle F. Biegasiewicz, Simon J. Cooper, Megan A. Emmanuel, David C. Miller* & Todd K. Hyster*

Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent ‘Ene’-Reductases

Braddock A. Sandoval, Andrew J. Meichan, Todd K. Hyster*

Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light

Megan A. Emmanuel, Norman R. Greenberg, Daniel G. Oblinsky, Todd K. Hyster*