PUBLICATIONS
2022
An Asymmetric sp3–sp3 Cross-Electrophile Coupling Using Biocatalysis
A Photoenzyme for Challenging Lactam Radical Cyclizations
Using Enzymes to Tame Nitrogen-Centered Radicals for Enantioselective Hydroamination
An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Catalysis
Workflow for Biocatalytic Reaction Performance Prediction and Analysis
2021
Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent “Ene”-Reductases
Engineering a Non-Natural Photoenzyme for Improved Photon Efficiency
Activation modes in biocatalytic radical cyclization reactions
Yuxuan Ye, Haigen Fu, Todd K Hyster*
Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins
Claire G. Page, Simon J. Cooper, Jacob S. DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Alyssa H. Antropow, Kurt W. Armbrust, J. Michael Ellis, Lawrence G. Hamann, Evan J. Horn, Kevin M. Oberg, Gregory D. Scholes, and Todd K. Hyster*
Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C–C Bond Forming Reactions
Haigen Fu, Heather Lam, Megan A. Emmanuel, Ji Hye Kim, Braddock A. Sandoval, and Todd K. Hyster*
Photoenzymatic Reductions Enabled by Direct Excitation of Flavin-Dependent “Ene”-Reductases
2020
Active-Site Environmental Factors Customize the Photophysics of Photoenzymatic Old Yellow Enzymes
Bryan Kudisch, Daniel G. Oblinsky, Michael J. Black, Anna Zieleniewska, Megan A. Emmanuel, Garry Rumbles, Todd K. Hyster, and Gregory D. Scholes*
Photoenzymatic Generation of Unstabilized Alkyl Radicals: An Asymmetric Reductive Cyclization
Phillip D. Clayman and Todd K. Hyster*
Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones
Pyridoxal-Catalyzed Racemization of α-Aminoketones Enables the Stereodivergent Synthesis of 1,2-Amino Alcohols Using Ketoreductases
Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts
Emerging strategies for expanding the toolbox of enzymes in biocatalysis
2019
Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases
Radical Biocatalysis: Using Non-Natural Single Electron Transfer Mechanisms to Access New Enzymatic Functions
Photoexcitation of flavoenzymes enables a stereoselective radical cyclization
Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases
Biocatalytic hydrogen atom transfer: an invigorating approach to free-radical reactions
2018
Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases
2017
Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent ‘Ene’-Reductases
2016
Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light
