PUBLICATIONS
2022
Haigen Fu, Jingzhe Cao, Tianzhang Qiao, Yuyin Qi, Simon J. Charnock, Samuel Garfinkle, Todd K. Hyster*
Photoinduced Dynamic Radical Processes for Isomerizations, Deracemizations, and Dynamic Kinetic Resolutions
Radical Termination via β-Scission Enables Photoenzymatic Allylic Alkylation Using “Ene”-Reductases
Netgie Laguerre, Paul S. Riehl, Daniel G. Oblinsky, Megan A. Emmanuel, Michael J. Black, Gregory D. Scholes, and Todd K. Hyster*
Using Enzymes to Tame Nitrogen-Centered Radicals for Enantioselective Hydroamination
Yuxuan Ye†, Jingzhe Cao†, Daniel G. Oblinsky, Deeptak Verma, Christopher K. Prier, Gregory D. Scholes & Todd K. Hyster*
Cell-Free CO2 Valorization to C6 Pharmaceutical Precursors via a Novel Electro-Enzymatic Process
Joshua Jack, Haigen Fu, Aaron Leininger, Todd K. Hyster, and Zhiyong Jason Ren
A Photoenzyme for Challenging Lactam Radical Cyclizations
Bryce T. Nicholls, Tianzhang Qiao, Todd K. Hyster
An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Catalysis
Paul S. Riehl, Jesmine Lim, James D. Finnigan, Simon J. Charnock, Todd K. Hyster
Workflow for Biocatalytic Reaction Performance Prediction and Analysis
Hanna D. Clements†, Autumn R. Flynn†, Bryce T. Nicholls, Daria Grosheva, Todd K. Hyster*, and Matthew S. Sigman*
2021
Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent “Ene”-Reductases
Xin Gao, Joshua R. Turek-Herman, Young Joo Choi, Ryan D. Cohen, and Todd K. Hyster*
Engineering a Non-Natural Photoenzyme for Improved Photon Efficiency
Bryce Nicholls, Daniel Oblinsky, Sarah Kurtoic, Daria Grosheva, Yuxuan Ye, Gregory Scholes, Todd Hyster*
Activation modes in biocatalytic radical cyclization reactions
Yuxuan Ye, Haigen Fu, Todd K Hyster*
Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins
Claire G. Page, Simon J. Cooper, Jacob S. DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Alyssa H. Antropow, Kurt W. Armbrust, J. Michael Ellis, Lawrence G. Hamann, Evan J. Horn, Kevin M. Oberg, Gregory D. Scholes, and Todd K. Hyster*
Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C–C Bond Forming Reactions
Haigen Fu, Heather Lam, Megan A. Emmanuel, Ji Hye Kim, Braddock A. Sandoval, and Todd K. Hyster*
Photoenzymatic Reductions Enabled by Direct Excitation of Flavin-Dependent “Ene”-Reductases
Braddock A. Sandoval, Phillip D. Clayman, Daniel G. Oblinsky, Seokjoon Oh, Yuji Nakano, Matthew Bird, Gregory D. Scholes, and Todd K. Hyster*
Chapter 12
Light-Driven Flavin-Based Biocatalysis
Daria Grosheva, Todd K. Hyster*
2020
Active-Site Environmental Factors Customize the Photophysics of Photoenzymatic Old Yellow Enzymes
Bryan Kudisch, Daniel G. Oblinsky, Michael J. Black, Anna Zieleniewska, Megan A. Emmanuel, Garry Rumbles, Todd K. Hyster, and Gregory D. Scholes*
Photoenzymatic Generation of Unstabilized Alkyl Radicals: An Asymmetric Reductive Cyclization
Phillip D. Clayman and Todd K. Hyster*
Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones
Jacob S. DeHovitz,Yong Yao Loh, Jacob A. Kautzky, Kazunori Nagao, Andrew J. Meichan, Motoshi Yamauchi, David W. C. MacMillan*, Todd K. Hyster*
Pyridoxal-Catalyzed Racemization of α-Aminoketones Enables the Stereodivergent Synthesis of 1,2-Amino Alcohols Using Ketoreductases
Jingzhe Cao and Todd K. Hyster*
Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts
Yuji Nakano, Michael J Black, Andrew J. Meichan, Braddock A Sandoval, Megan Chung, Kyle Biegasiewicz, Tianyu Zhu, Todd K. Hyster*
Emerging strategies for expanding the toolbox of enzymes in biocatalysis
Braddock A. Sandoval, Todd K. Hyster*
2019
Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases
Michael J. Black, Kyle F. Biegasiewicz, Andrew J. Meichan, Daniel G. Oblinsky, Bryan Kudisch, Gregory Scholes, Todd Hyster*
Radical Biocatalysis: Using Non-Natural Single Electron Transfer Mechanisms to Access New Enzymatic Functions
Todd K. Hyster
Photoexcitation of flavoenzymes enables a stereoselective radical cyclization
Kyle F. Biegasiewicz, Simon J. Cooper, Xin Gao, Daniel G. Oblinsky, Ji Hye Kim, Samuel E. Garfinkle, Leo A. Joyce, Braddock A. Sandoval, Gregory D. Scholes*, Todd K. Hyster*
Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases
Braddock A. Sandoval, Sarah I. Kurtoic, Megan M. Chung, Kyle F. Biegasiewicz, Todd K. Hyster*
Biocatalytic hydrogen atom transfer: an invigorating approach to free-radical reactions
Yuji Nakano, Kyle F Biegasiewicz, Todd K Hyster*
2018
Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases
Kyle F. Biegasiewicz, Simon J. Cooper, Megan A. Emmanuel, David C. Miller* & Todd K. Hyster*
2017
Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent ‘Ene’-Reductases
Braddock A. Sandoval, Andrew J. Meichan, Todd K. Hyster*
2016
Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light
Megan A. Emmanuel, Norman R. Greenberg, Daniel G. Oblinsky, Todd K. Hyster*
