PUBLICATIONS

PHOTOENZYMATIC REDUCTIONS ENABLED BY DIRECT EXCITATION OF FLAVIN-DEPENDENT “ENE”-REDUCTASES

J. Am. Chem. Soc. 2020

Braddock A. Sandoval , Phillip D. Clayman, Daniel G. Oblinsky, Seokjoon Oh, Yuji Nakano, Matthew Bird, Gregory D. Scholes, and Todd K. Hyster*

ACTIVE-SITE ENVIRONMENTAL FACTORS CUSTOMIZE THE PHOTOPHYSICS OF PHOTOENZYMATIC OLD YELLOW ENZYMES

J. Phys. Chem. B 2020,

Bryan Kudisch, Daniel G. Oblinsky, Michael J. Black, Anna Zieleniewska, Megan A. Emmanuel, Garry Rumbles, Todd K. Hyster, and Gregory D. Scholes

ChemRxiv,2020

Claire G. Page, Simon J. Cooper, Jacob S. DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Alyssa H. Antropow, Kurt W. Armburst, J. Michael Ellis, Lawrence G. Hamann, Evan J. Horn, Kevin M. Oberg, Gregory D. Scholes, Todd K. Hyster

QUATERNARY CHARGE-TRANSFER COMPLEX ENABLES PHOTOENZYMATIC IN-TERMOLECULAR HYDROALKYLATION OF OLEFINS

PHOTOENZYMATIC GENERATION OF UNSTABILIZED ALKYL RADICALS: AN ASYMMETRIC REDUCTIVE CYCLIZATION

Phillip D. Clayman and Todd K. Hyster

J. Am. Chem. Soc. 2020, 142, 37, 15673–15677, DOI 

STATIC TO INDUCIBLY DYNAMIC STEREOCONTROL: THE CONVERGENT USE OF RACEMIC Β-SUBSTITUTED KETONES

Jacob S. DeHovitz,Yong Yao Loh, Jacob A. Kautzky, Kazunori Nagao, Andrew J. Meichan, Motoshi Yamauchi, David W. C. MacMillan, Todd K. Hyster

Science 2020, 369, 1113-1118, DOI :10.1126/science.abc9909

PYRIDOXAL-CATALYZED RACEMIZATION OF α-AMINOKETONES ENABLES THE STEREODIVERGENT SYNTHESIS OF 1,2-AMINO ALCOHOLS USING KETOREDUCTASES

Jingzhe Cao, Todd K. Hyster

ACS Catal. 2020, 10, 6171−6175, DOI :10.1021/acscatal.0c01502

PHOTOENZYMATIC HYDROGENATION OF HETEROAROMATIC OLEFINS USING ‘ENE’‐REDUCTASES WITH PHOTOREDOX CATALYSTS

Angew. Chem. Int. Ed., 2020, DOI : 10.1002/ange.202003125

Yuji Nakano, Michael J Black, Andrew J. Meichan, Braddock A Sandoval, Megan Chung, Kyle Biegasiewicz, Tianyu Zhu, Todd K. Hyster

EMERGING STRATEGIES FOR EXPANDING THE TOOLBOX OF ENZYMES IN BIOCATALYSIS

Braddock A. Sandoval, Todd K. Hyster

Curr. Opin. Chem. Biol., 2020, 55, 45-51. 

Michael J. Black, Kyle F. Biegasiewicz, Andrew J. Meichan, Daniel G. Oblinsky, Bryan Kudisch, Gregory Scholes, Todd Hyster

PHOTOEXCITATION OF FLAVOENZYMES ENABLES A STEREOSELECTIVE RADICAL CYCLIZATION

Science 2019, 364, 1166–1169 

 Kyle F. Biegasiewicz, Simon J. Cooper, Xin Gao, Daniel G. Oblinsky, Ji Hye Kim, Samuel E. Garfinkle, Leo A. Joyce, Braddock A. Sandoval, Gregory D. Scholes, Todd K. Hyster.

RADICAL BIOCATALYSIS: USING NON-NATURAL SINGLE ELECTRON TRANSFER MECHANISMS TO ACCESS NEW ENZYMATIC FUNCTIONS

 Todd K. Hyster

Synlett 2019, 30, A–G

PHOTOENZYMATIC CATALYSIS ENABLES RADICAL-MEDIATED

KETONE REDUCTION IN 'ENE'-REDUCTASES

Angew. Chem. Int. Ed., DOI: 10.1002/anie.201902005

Braddock A. Sandoval, Sarah I. Kurtoic, Megan M. Chung, Kyle F. Biegasiewicz, Todd K. Hyster

BIOCATALYTIC HYDROGEN ATOM TRANSFER: AN INVIGORATING APPROACH TO FREE-RADICAL REACTIONS

Yuji Nakano, Kyle F Biegasiewicz, Todd K Hyster

Curr. Opin. Chem. Biol., 2019, 49, 16-24.

ENANTIOSELECTIVE HYDROGEN ATOM TRANSFER: DISCOVERY OF CATALYTIC PROMISCUITY IN FLAVIN-DEPENDENT ‘ENE’-REDUCTASES

Braddock A. Sandoval
Andrew J. Meichan, Todd K. Hyster

J. Am. Chem. Soc. 2017, 139, 11313. 

ACCESSING NON-NATURAL REACTIVITY BY IRRADIATING NICOTINAMIDE-DEPENDENT ENZYMES WITH LIGHT

Nature 2016, 540, 414.

Megan A. Emmanuel, Norman R. Greenberg, Daniel G. Oblinsky, Todd K. Hyster

GENETIC OPTIMIZATION OF METALLOENZYMES: ENHANCING ENZYMES FOR NON-NATURAL REACTIONS

Todd K. Hyster, Thomas R. Ward

Angew. Chem. Int. Ed. 2016, 55, 7344.