PUBLICATIONS

PHOTOENZYMATIC REDUCTIONS ENABLED BY DIRECT EXCITATION OF FLAVIN-DEPENDENT “ENE”-REDUCTASES

Braddock A. Sandoval , Phillip D. Clayman, Daniel G. Oblinsky, Seokjoon Oh, Yuji Nakano, Matthew Bird, Gregory D. Scholes, and Todd K. Hyster*

J. Am. Chem. Soc. 2020

ACTIVE-SITE ENVIRONMENTAL FACTORS CUSTOMIZE THE PHOTOPHYSICS OF PHOTOENZYMATIC OLD YELLOW ENZYMES

Bryan Kudisch, Daniel G. Oblinsky, Michael J. Black, Anna Zieleniewska, Megan A. Emmanuel, Garry Rumbles, Todd K. Hyster, and Gregory D. Scholes

J. Phys. Chem. B 2020, 124, 11236-11249.

QUATERNARY CHARGE-TRANSFER COMPLEX ENABLES PHOTOENZYMATIC IN-TERMOLECULAR HYDROALKYLATION OF OLEFINS

Claire G. Page, Simon J. Cooper, Jacob S. DeHovitz, Daniel G. Oblinsky, Kyle F. Biegasiewicz, Alyssa H. Antropow, Kurt W. Armburst, J. Michael Ellis, Lawrence G. Hamann, Evan J. Horn, Kevin M. Oberg, Gregory D. Scholes, Todd K. Hyster

J. Am. Chem. Soc. 2021, 143, 97-102.

PHOTOENZYMATIC GENERATION OF UNSTABILIZED ALKYL RADICALS: AN ASYMMETRIC REDUCTIVE CYCLIZATION

Phillip D. Clayman and Todd K. Hyster

J. Am. Chem. Soc. 2020, 142,15673–15677

STATIC TO INDUCIBLY DYNAMIC STEREOCONTROL: THE CONVERGENT USE OF RACEMIC β-SUBSTITUTED KETONES

Jacob S. DeHovitz,Yong Yao Loh, Jacob A. Kautzky, Kazunori Nagao, Andrew J. Meichan, Motoshi Yamauchi, David W. C. MacMillan, Todd K. Hyster

Science 2020, 369, 1113-1118

PYRIDOXAL-CATALYZED RACEMIZATION OF α-AMINOKETONES ENABLES THE STEREODIVERGENT SYNTHESIS OF 1,2-AMINO ALCOHOLS USING KETOREDUCTASES

Jingzhe Cao, Todd K. Hyster

ACS Catal. 2020, 10, 6171−6175

PHOTOENZYMATIC HYDROGENATION OF HETEROAROMATIC OLEFINS USING ‘ENE’‐REDUCTASES WITH PHOTOREDOX CATALYSTS

Yuji Nakano, Michael J Black, Andrew J. Meichan, Braddock A Sandoval, Megan Chung, Kyle Biegasiewicz, Tianyu Zhu, Todd K. Hyster

Angew. Chem. Int. Ed. 2020, 59, 10484-10488.

EMERGING STRATEGIES FOR EXPANDING THE TOOLBOX OF ENZYMES IN BIOCATALYSIS

Braddock A. Sandoval, Todd K. Hyster

Curr. Opin. Chem. Biol. 2020, 55, 45-51. 

ASYMMETRIC REDOX-NEUTRAL RADICAL CYCLIZATION CATALYZED BY FLAVIN-DEPENDENT ‘ENE’-REDUCTASES

Michael J. Black, Kyle F. Biegasiewicz, Andrew J. Meichan, Daniel G. Oblinsky, Bryan Kudisch, Gregory Scholes, Todd Hyster

Nature Chemistry 2019,12, 71–75.

PHOTOEXCITATION OF FLAVOENZYMES ENABLES A STEREOSELECTIVE RADICAL CYCLIZATION

Kyle F. Biegasiewicz, Simon J. Cooper, Xin Gao, Daniel G. Oblinsky, Ji Hye Kim, Samuel E. Garfinkle, Leo A. Joyce, Braddock A. Sandoval, Gregory D. Scholes, Todd K. Hyster.

Science 2019, 364, 1166–1169

RADICAL BIOCATALYSIS: USING NON-NATURAL SINGLE ELECTRON TRANSFER MECHANISMS TO ACCESS NEW ENZYMATIC FUNCTIONS

 Todd K. Hyster

Synlett 2019, 30, 248-254.

PHOTOENZYMATIC CATALYSIS ENABLES RADICAL-MEDIATED KETONE REDUCTION IN 'ENE'-REDUCTASES

Braddock A. Sandoval, Sarah I. Kurtoic, Megan M. Chung, Kyle F. Biegasiewicz, Todd K. Hyster

Angew. Chem. Int. Ed. 2019, 58, 8714-8718.

BIOCATALYTIC HYDROGEN ATOM TRANSFER: AN INVIGORATING APPROACH TO FREE-RADICAL REACTIONS

Yuji Nakano, Kyle F Biegasiewicz, Todd K Hyster

Curr. Opin. Chem. Biol. 2019, 49, 16-24.

CATALYTIC PROMISCUITY ENABLED BY PHOTOREDOX CATALYSIS IN NICOTINAMIDE-DEPENDENT OXIDOREDUCTASES

Kyle F. Biegasiewicz, Simon J. Cooper, Megan A. Emmanuel, David C. Miller & Todd K. Hyster

Nature Chemistry 2018, 10, 770.

ENANTIOSELECTIVE HYDROGEN ATOM TRANSFER: DISCOVERY OF CATALYTIC PROMISCUITY IN FLAVIN-DEPENDENT ‘ENE’-REDUCTASES

Braddock A. Sandoval, Andrew J. Meichan, Todd K. Hyster

J. Am. Chem. Soc. 2017, 139, 11313.

ACCESSING NON-NATURAL REACTIVITY BY IRRADIATING NICOTINAMIDE-DEPENDENT ENZYMES WITH LIGHT

Megan A. Emmanuel, Norman R. Greenberg, Daniel G. Oblinsky, Todd K. Hyster

Nature 2016, 540, 414.

GENETIC OPTIMIZATION OF METALLOENZYMES: ENHANCING ENZYMES FOR NON-NATURAL REACTIONS

Todd K. Hyster, Thomas R. Ward 

Angew.Chem. Int.Ed. 2016, 55,7344 –7357