THE HYSTER GROUP
Developing Biocatalysts For The 21st Century
Activation modes in biocatalytic radical cyclization reactions
Yuxuan Ye, Haigen Fu, Todd K. Hyster
Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C–C Bond Forming Reactions
Haigen Fu, Heather Lam, Megan A. Emmanuel, Ji Hye Kim, Braddock A. Sandoval, and Todd K. Hyster*
Photoenzymatic Reductions Enabled by Direct Excitation of Flavin-Dependent “Ene”-Reductases
Braddock A. Sandoval, Phillip D. Clayman, Daniel G. Oblinsky, Seokjoon Oh, Yuji Nakano, Matthew Bird, Gregory D. Scholes, and Todd K. Hyster*
ADAPTIVE ENZYME DISCOVERY
In an effort to develop more efficient and selective synthetic routes of valuable organic molecules, our group is focused on discovering versatile biocatalysts that can be used to effect a variety of synthetic reactions.
Our research emphasis is on the convergence of small molecule catalysis with enzymes, whereby the benefits of each are harnessed to uncover previously unknown chemical transformations with high selectivity.